At the C667 location on the gene a "normal" person would get a C from both parents, a heterozygous mutation means you got a C from one parent and a T from the other. A Homozygous mutation would be a T/T, one T from each parent. Same for the A1298 mutation. I have the A1298C, Homozygous, which means i got two copies one from each parent... Yeyyyyy!! Not!
Having either one of these mutations means that your body does not process B vitamins, specially folic acid (which is a synthetic folate), properly. It doesn't mean i need to get more folic acid because the synthetic folate will just sit in my body unprocessed and can cause inflammation and other issues; This diagnosis means i need a different form of B Vitamins for my body to be able to absorb it.
Folate deficiency can be correlated with many issues and to list just a few:
Male and Female Infertility
Some people call it the mother (bad word) gene.
My Dr said that the C667 mutation is way worst than the one i have cause that's the one that can cause strokes and blood clotting. Also from what i read if you have that mutation you should not be eating any gluten or dairy products from cows, so more or less a strict Paleo diet.
But still not being able to process B vitamins is a big deal. My Dr prescribed a super folic acid (4 times the regular folic acid) called Folgard which i'm not crazy about using since it's still a synthetic folate and i will NOT be getting that prescription. I'm either going to make him change it to Metanx which contains the active forms of the B vitamins or i will be buying my supplements from www.seekinghelth.com.